Secrets in the war to stop shortsightedness from increasing

Trying to stop myopia progression is like deciding to go on a diet. Seriously. I'll get to that eventually but before we get too philosophical, let's take a step back.

Currently, more than 50% of twelve year olds in Singapore need to wear glasses because of myopia. And by the time the boys enter the army at 18 years of age, it will have increased to 80%. Unfortunately, myopia is a problem that continues to worsen as children grow up, usually stabilizing by the late teenage years. By this time, it is not uncommon to see patients with myopia of -6D and above. High myopia of course, can give rise to other problems such as an increased risk of retinal detachments and an earlier onset of cataracts.

Myopia or shortsightedness arises because of an imbalance between the focusing power of the cornea and lens of the eye, versus the length of the eyeball. In the type of myopia that arises in children, it is mainly a problem of the eyeball growing too long, ie axial myopia.

For many decades now, research has been ongoing both to find a cause of this abnormal eyeball growth, as well as to find ways to stop it or at least to slow it down. Because the actual cause and mechanism are not known, methods that have been tried are all based on theories or empirical data. Let's take a look at the things that have been tried.

Things that have been tried and failed

1. Timolol eyedrops to lower eye pressure.
Since eye pressure may potentially stretch an eyeball and make it bigger and longer, people tried to see if lowering the eye pressure could stop the eyeball from enlarging. Unfortunately Timolol eyedrops did not work. However, it remains to be seen whether more powerful pressure lowering medications like bimatoprost may have an effect.

Things that may work (either the evidence or effect is weak)
1. Glasses which reduce peripheral hyperopic defocus (Myovision by Zeiss)
These glasses appeared to have an effect in younger children who had myopic parents. Why it would only work in this subgroup of people is unknown but could reflect a weak effect or a chance finding.
Sankaridurg P, Donovan L, Varnas S, et al. Spectacle lenses designed to reduce progression of myopia: 12-month results. Optom Vis Sci 2010; 87: 631–41. 

2. Rigid gas permeable (RGP, or semi hard) contact lenses
At the age of about 11 I was introduced to 'hard' or RGP contact lenses in the hope that it could slow down the rate of increase of my myopia. In fact in my case, it wasn't that successful in this regard. A well conducted trial showed that RGP lenses do not slow down the growth of the eyeball, but may have an effect by reducing the steepening of the cornea.# This may be only a temporary effect from the pressure of the lens on the eyeball.
#Walline et al. A randomized trial of the effects of rigid contact lenses on myopia progression. Arch Ophthalmol. 2004 Dec;122(12):1760-6.

3.Orthokeratology
Orthokeratology (OK or Corneal Refractive Therapy/CRT) takes the concept of corneal flattening using pressure from a lens one step further. In this method, RGP lenses of a special shape are worn to sleep. The lenses press on the patient's cornea during sleep, so that during the day the lens can be removed, and the cornea retains the ideal shape which corrects the long/shortsightedness and astigmatism. After a few days of not wearing the lens to sleep, this effect is lost, so the power lowering effect is temporary.

But does it stop myopia from increasing?

Walline JJ, Jones LA, Sinnott LT. Corneal reshaping and myopia progression. Br J Ophthalmol. 2009 Sep;93(9):1181-5.

The above study showed that yes, it seemed that orthokeratology can slow down the growth of the eyeball compared with soft contact lenses. This effect is not as strong as 1% atropine eyedrops (0.25mm elongation with OK versus -0.02+/-0.35 mm with atropine at 2 years).

In other words, OK lenses had an effect somewhere between soft contact lenses and 1% atropine, but without the side effects of the atropine. Do consider though, that wearing contact lenses to sleep is generally felt to increase the risk of eye infections.

Things that work (with strong evidence and strong effect)

1. Atropine
The idea of using atropine came about because of its well known ability to relax the ciliary muscles in the eye (which are used for near focusing). Since as the theory goes, too much near work is related to shortsightedness, and near work results in prolonged contraction of this muscle, would relaxing the muscle have an effect on myopia progression? The results of well conducted studies show that yes, indeed atropine has a powerful effect on slowing or stopping the worsening of myopia.

There are two concentrations in common usage: 1% (stronger) and 0.01% (weaker). The 1% concentration is very effective but has side effects of causing sensitivity to bright lights and temporary inability to focus for near. These are reduced by using special progressive glasses that turn dark in bright light. With the 0.01% concentration, there are no side effects but the effects of slowing down myopia are not as pronounced. Which specific medicine is used depends on the degree of shortsightedness, how fast it is progressing and the child's tolerance to the side effects of the stronger concentration. Read more about this at my other post on atropine and myopia.

2. Outdoor time
2 generations ago, it was much less common to see a shortsighted person in Singapore, despite people having essentially the same set of genes. Other things have changed, notably our environment and activities.

Increasingly, evidence points to the importance of outdoor activities in reducing the rates of myopia and its progression.# What is it about being outdoors that slows myopia? Many people think it is because we get to see things far away when we step outdoors, but this effect of distance versus near visual work has been shown to be only a weak one.*
#Rose KA, Morgan IG, Ip J, et al. Outdoor activity reduces the prevalence of myopia in children. Ophthalmology 2008; 115: 1279–85.
*Mutti DO, Mitchell GL, Moeschberger ML, Jones LA, Zadnik K. Parental myopia, near work, school achievement, and children’s refractive error. Invest Ophthalmol Vis Sci 2002; 43: 3633–40.

In fact, it is likely to be due to the difference in amount of light being seen by the eye, when comparing being indoors versus outdoors.

When we step outdoors, even at 5 or 6pm in the evening, we are typically being exposed to much more light than we get even with the brightest lamps indoors. It has been shown that bright light leads to the release of more retinal dopamine, a chemical which may play a role in controlling eye growth. It is intriguing that using a chemical to block dopamine in animals can also block the protective effect of bright light.#
#Ashby RS, Schaeff el F. The eff ect of bright light on lens compensation in chicks. Invest Ophthalmol Vis Sci 2010; 51: 5247–53.

SO.....
It is said that in losing weight, '..., you must accept that this is your new lifestyle of eating healthy and being physically active...' http://www.webmd.com/diet/features/10-diet-secrets-lasting-weight-loss-success

And equally, in trying to control myopia, the patient must accept a new lifestyle of regular outdoor activity (in sunlight) and being more active. At least 1-2 hours everyday. As a follow on from that, it's also important to ensure that when indoors/doing near work, that the child has a brightly illuminated environment. It does not matter what type of light it is (eg sunlight by the window, fluorescent, LED etc), as long as it is bright. Failing which, the most effective treatment so far is atropine eyedrops.

No, wait..... Actually it's easier to control myopia than to go on diet. If only our waistlines would stabilise after a certain age (like myopia), so that we don't have to worry about it any more after that!

References:
Lancet 2012; 379: 1739–48
Ophthalmology 2002;109:415–427

Soft contact lenses or hard contact lenses?

Contact lenses are a very popular form of vision correction. In Singapore, it is estimated that 600000 people wear them (ST, Sep 1 2012 'Contact lenses safe, provided proper care is taken'), with a very low risk of complications.

Generally, contact lenses can be divided into soft and hard varieties. Soft lenses tend to be large in diameter and are flexible, so they can be folded. They are much more comfortable to wear, and currently the most commonly used ones are of the disposable type. Although soft contact lenses first became available in 1971, the disposable type only became available from 1987 onwards.

Nowadays, there are daily disposable, 2 weekly disposable, and monthly disposable types. And of course, there are the longer term, permanent lenses which actually are used for about 1 year before they need to be replaced. Daily disposable lenses are expensive, but they are least likely among soft contact lenses to cause problems such as allergies or infections, unless the user does not wear them according to instructions. Daily disposable lenses also are thinner, and so less likely to cause or exacerbate dry eye situations. Even 2 weekly or monthly disposable types are worn successfully by many people, and are most cost efficient for those who wear lenses on a daily basis.

Current 'hard' or 'semi-hard' lenses usually refer to corneal rigid gas permeable lenses (RGP), and these were first introduced in 1978. In actual fact there are other types of hard lenses, such as scleral lenses, and there are even hybrid hard lenses with a soft skirt at the edge, but these are more rarely used.

In 2012, RGP lenses made up 9% of contact lenses worn in the US. Source: Contact Lens Spectrum, January 2013. 

They are less widely used than soft lenses, because there is an initial period when RGP wearers will feel the lens in their eye. This uncomfortable sensation is akin to having an eyelash in the eye-ie it is not very painful but in the initial stages can cause tearing and bother the wearer. Once over this period (up to 2-3 weeks), the lens is as comfortable as soft lenses, and the RGP lens really begins to shine. Occasionally, if a bit of dust gets under the contact lens, that can cause eye pain, but a quick rinse with even tap water will clear this easily.

The benefits of RGP lens wear are many, among which are sharp vision (usually sharper than soft contact lenses or spectacles), very good oxygen permeability (yes, your cornea needs to breathe oxygen in the air!), less tendency to be affected by dry eyes, and very good durability.

One reason why some young children used to be started on RGP lenses was a belief that wearing them could slow the progression of shortsightedness (Myopia). However, a study done 10 years ago (Arch Ophthalmol. 2004;122(12):1760-1766) showed that there was no difference in growth of eyeball length between the soft contact lens wearers vs the RGP lens wearers. This suggests that RGP lenses have no real ability to  retard the progression of shortsightedness.

There is a special class of RGP lenses called orthokeratology lenses which are worn to sleep, and are worn with the intention to flatten an area of the cornea. I will cover these lenses in a future post as they are used in a radically different way compared to other contact lenses.

Should one go for soft lenses or hard lenses? I would say that for the majority of people, soft contact lenses are best because of the comfort, ease of wear and care. They are good for occasional wearers and those with otherwise healthy eyes.

RGP lenses would be especially useful for those with the desire or need to see with very sharp vision, and those for whom the extra thickness of soft contact lenses might give rise to problems eg those with very high spectacle power, or those with dry eyes.

I guess I am partial to RGP lenses, having worn them myself for over 30 years. The only thing I avoid doing with any regularity is swimming, even though it is possible to wear goggles with them on. I have gotten so used to them that I actually find it easier to wear them than soft contact lenses.

Contact lens FAQs

Problems such as shortsightedness have become so common in Singapore that by 12 years of age, about 60% of children are already wearing glasses. Although spectacle wearing is effective and safe, they are not always the most convenient of things to use.

At my clinic, we often come across patients who are either keen to start wearing contact lenses or are already wearing them but have some nagging questions about them that they just thought of. Hopefully this post, which is in a Q+A format, will help to answer those queries.

1. Can my contact lenses get lost in my eyes?

Contact lenses cannot be lost in the eyes, because there are natural pockets at the side of the eyes which prevent the lenses from going further backwards. However, they may sometimes slip off the cornea onto the white part of the eye. If this is noticed, you may reposition it yourself, or see an eye care professional for help.

2. If I’m playing soccer and the ball hits me near or on my eye, will my lenses break or tear in my eyes?

Direct impact by the soccer ball onto the eyeball will cause injury of varying severity depending on the force of the trauma. A soft contact lens will not generally break or tear due to its flexibility. A hard contact lens could theoretically break although that is also very unlikely due to the softness of the surrounding tissues. What happens more commonly is the lens is knocked or rubbed off the eye. Surface abrasions of the cornea may be caused as a result.

4. I want to wear coloured lenses to look different sometimes... Will these lenses damage my eyes?

Coloured or tinted lenses are available from major manufacturers such as Cibavision. These are generally safe to use but like all contact lenses should be dispensed only after fitting by an eye care professional. Buying these lenses from internet sources, or from manufacturers with an unknown reputation risks severe damage to the eye from problems such as infection, irritation from chemicals in the soaking solution, or poorly fitting lenses.

5. I heard that I could catch Acanthamoeba infection by swimming without removing my contact lenses. This parasite can burrow into my eyes and make me blind. Is this true?

Acanthamoeba is a one-celled protozoan parasite that is found in many places in our environment, including tap water. If contaminated water from the swimming pool enters the eye, Acanthamoeba can stick to the contact lens and establish an infection on the surface of the eye. If not treated, a severe corneal ulcer can develop causing blindness. In general contact lenses should be removed before swimming and they should not be cleaned with tap water or home made saline to avoid this infection.

6. I have no access to saline solution and even tap water. There is a problem with one of my lenses (the edge has curled inwards slightly and is causing me pain). What can I do? Can I remove the affected lens and re-wet it with saliva?

The best thing to do is to remove the contact lens and discard it. Saliva should not be used because the mouth is filled with bacteria and using saliva is going to contaminate the lens, thereby making it very likely for a corneal infection to occur.

7. I fell asleep overnight with my lenses on. Will they get stuck to my eyes?

Sleeping with contact lenses on for any length of time raises the risk of infection and should not be done for any length of time. Even without an infection, lens adherence or sticking to the eye is very common after sleeping with them on and is due to a combination of dryness and the pressure of the eyelids. This sticking is not permanent, and if it happens, the wearer should wet the eyes with re-wetting solution or artificial tears, and then attempt to remove the lens after a few minutes. If this cannot be done, then an eye care professional should be consulted for removal of the lens.

8. I use daily disposables. However, I’ve been wearing them continuously for a week (I don’t remove them). How long can I overuse disposable lenses?

It is very dangerous to wear daily disposable lenses in such a fashion. The lenses become coated with deposits and sooner or later an infection develops or the eye becomes red and irritated from the lack of oxygen and deposits. Disposable contact lenses should be changed strictly according to the schedule recommended by the manufacturer.

9. I was travelling overseas when I ran out of saline solution. I used tap water to rinse my lenses instead. After a few days, I started noticing coloured spots on my lenses. What is happening to my lenses?

It is not possible to say with certainty what these spots are but they could be mineral deposits if the tap water was hard (with a high concentration of dissolved substances). Worse, they could even be fungus growing on the contact lens. These lenses should be discarded immediately.

11. Do the new “HD” soft lenses work for people with astigmatism? Can people with severe astigmatism wear such “HD” lenses? Are RGP lenses still preferred for people with astigmatism?

“HD” refers to optimized optics which include aspheric designs but it does not necessarily mean that the lens will have a toric component to correct astigmatism. A person with severe astigmatism needs either a toric soft lens or a rigid gas permeable (RGP, otherwise known as hard) lens. RGP lenses correct astigmatism very well and possibly provide the sharpest vision among the types of contact lenses. However this must also be balanced with comfort issues.

12. I have lazy eyes. Will contact lenses help my condition? What types of contact lenses are best suited for my condition?

Lazy eyes (amblyopia) develop during childhood because a disturbance of vision prevents normal development of the nerve pathways between the eye and brain. Later on in life, vision remains blurred in the lazy eye even when glasses or contact lenses are worn, because the problem has to do with the nerves and brain, and is not related only to spectacle power. If lazy eyes are detected in childhood, the better eye is patched and the child is forced to use the lazy eye to see, with the use of glasses or contact lenses as appropriate. Beyond the age of about 10 years, patching is no longer useful. Older children and adults with lazy eye are now treatable with a revolutionary computer based training program called Neurovision (see http://www.neurovision.com.sg/). This presents customised images to the patient and over a period of several months improves nerve connections and vision even in adults with lazy eye. As such, lazy eyes are not treated by particular contact lenses per se, but the contact lenses or glasses will help with any long/short-sightedness or astigmatism that is present.